Cell Senescence Entries for KDM4A

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Unclear
Observations
The expression of JMJD2A (KDM4A) inhibited Ras-mediated CHD5 induction, leading to reduced p53 pathway activity. In addition, JMJD2A overexpression in mouse and human lung cancers was shown. Depletion of JMJD2A human lung cancer cells bearing an activated K-Ras allele triggered senescence.
Primary Reference

    KDM4A Gene Information

    HGNC symbol
    KDM4A 
    Aliases
    JMJD2; JHDM3A; JMJD2A; TDRD14A 
    Common name
    lysine demethylase 4A 
    Entrez Id
    9682
    Description
    This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

    KDM4A Ontologies

    Gene Ontology
    Process: GO:14898; cardiac muscle hypertrophy in response to stress
    GO:70544; histone H3-K36 demethylation
    GO:16577; histone demethylation
    GO:48712; negative regulation of astrocyte differentiation
    GO:10507; negative regulation of autophagy
    GO:60548; negative regulation of cell death
    GO:10629; negative regulation of gene expression
    GO:1900113; negative regulation of histone H3-K9 trimethylation
    GO:45892; negative regulation of transcription, DNA-templated
    GO:55114; oxidation-reduction process
    GO:10628; positive regulation of gene expression
    And 5 more GO terms
    Cellular component: GO:5829; cytosol
    GO:1650; fibrillar center
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5721; pericentric heterochromatin
    Function: GO:32452; histone demethylase activity
    GO:51864; histone demethylase activity (H3-K36 specific)
    GO:35064; methylated histone binding
    GO:5515; protein binding
    GO:31625; ubiquitin protein ligase binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of KDM4A in Model Organisms

    Danio rerio
    si:ch211-215f22.3
    Mus musculus
    Kdm4a
    Rattus norvegicus
    Kdm4a

    External links

    OMIM
    609764
    Ensembl
    ENSG00000066135
    Entrez Gene
    9682
    UniGene
    155983
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    KDM4A
    GeneCards
    KDM4A