Cell Senescence Entries for KCNJ12

Cell Types
Prostate cancer, Breast cancer, Gastric cancer
Cell Lines
PC-3, DU145, LNCaP, MKN74, SNU-484, SNU-638, SNU-668, MCF-7, SK-BR3, T47D
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
Knockdown of Kir2.2 (KCNJ12) induced a significant increase in reactive oxygen species, followed by growth arrest, increased SA-beta-galactosidase activity and upregulated senescence markers in cancer cells lacking functional p53, p16, or Rb (including prostate, stomach, and breast cancer cells). Conversely, overexpression of Kir2.2 decreased doxorubicin-induced ROS accumulation and cell growth inhibition.
Primary Reference

    KCNJ12 Gene Information

    HGNC symbol
    KCNJ12 
    Aliases
    IRK2; hIRK; IRK-2; hIRK1; KCNJN1; Kir2.2; Kir2.2v; kcnj12x; hkir2.2x 
    Common name
    potassium voltage-gated channel subfamily J member 12 
    Entrez Id
    3768
    Description
    This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

    KCNJ12 Ontologies

    Gene Ontology
    Process: GO:61337; cardiac conduction
    GO:6936; muscle contraction
    GO:10107; potassium ion import
    GO:6813; potassium ion transport
    GO:51289; protein homotetramerization
    GO:8016; regulation of heart contraction
    GO:34765; regulation of ion transmembrane transport
    Cellular component: GO:5887; integral component of plasma membrane
    GO:31224; intrinsic component of membrane
    GO:5886; plasma membrane
    Function: GO:15467; G-protein activated inward rectifier potassium channel activity
    GO:5242; inward rectifier potassium channel activity
    Show all GO terms

    Homologs of KCNJ12 in Model Organisms

    No homologs found

    External links

    OMIM
    602323
    Ensembl
    ENSG00000184185
    Entrez Gene
    3768
    UniGene
    200629
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    KCNJ12
    GeneCards
    KCNJ12