Cell Senescence Entries for ITSN2

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
Hs68, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
Overexpression of ITSN2 independently induced expression of the p16 and p57, two senescence associated cyclin-dependent kinase inhibitors, which act to block Rb inactivation as downstream effectors of ING1a. ITSN2 was also expressed in normally senescing cells, consistent with elevated levels of ING1a inducing ITSN2 as part of a normal senescence program. Knockdown of ITSN2 blocked the ability of ING1a to induce a senescent phenotype, confirming that ITSN2 is a major transducer of ING1a-induced senescence signalling.
Primary Reference

    ITSN2 Gene Information

    HGNC symbol
    ITSN2 
    Aliases
    SWA; SWAP; SH3D1B; SH3P18; PRO2015 
    Common name
    intersectin 2 
    Entrez Id
    50618
    Description
    This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]

    ITSN2 Ontologies

    Gene Ontology
    Process: GO:6897; endocytosis
    GO:43547; positive regulation of GTPase activity
    GO:1903861; positive regulation of dendrite extension
    GO:9967; positive regulation of signal transduction
    GO:35023; regulation of Rho protein signal transduction
    Cellular component: GO:5813; centrosome
    GO:5737; cytoplasm
    GO:70062; extracellular exosome
    Function: GO:5089; Rho guanyl-nucleotide exchange factor activity
    GO:5070; SH3/SH2 adaptor activity
    GO:5509; calcium ion binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of ITSN2 in Model Organisms

    Caenorhabditis elegans
    itsn-1
    Drosophila melanogaster
    Dap160
    Mus musculus
    Itsn2
    Rattus norvegicus
    Itsn2

    External links

    OMIM
    604464
    Ensembl
    ENSG00000198399
    Entrez Gene
    50618
    UniGene
    432562
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ITSN2
    GeneCards
    ITSN2