Cell Senescence Entries for ITPKB

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    ITPKB Gene Information

    HGNC symbol
    ITPKB 
    Aliases
    IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB 
    Common name
    inositol-trisphosphate 3-kinase B 
    Entrez Id
    3707
    Description
    The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

    ITPKB Ontologies

    Gene Ontology
    Process: GO:165; MAPK cascade
    GO:7166; cell surface receptor signaling pathway
    GO:71277; cellular response to calcium ion
    GO:35726; common myeloid progenitor cell proliferation
    GO:43647; inositol phosphate metabolic process
    GO:32957; inositol trisphosphate metabolic process
    GO:2262; myeloid cell homeostasis
    GO:45638; negative regulation of myeloid cell differentiation
    GO:33030; negative regulation of neutrophil apoptotic process
    GO:46579; positive regulation of Ras protein signal transduction
    GO:46638; positive regulation of alpha-beta T cell differentiation
    And 4 more GO terms
    Cellular component: GO:5829; cytosol
    GO:16020; membrane
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:5516; calmodulin binding
    GO:8440; inositol-1,4,5-trisphosphate 3-kinase activity
    GO:5515; protein binding
    Show all GO terms

    Homologs of ITPKB in Model Organisms

    Danio rerio
    itpkb
    Mus musculus
    Itpkb
    Rattus norvegicus
    Itpkb

    External links

    OMIM
    147522
    Ensembl
    ENSG00000143772
    Entrez Gene
    3707
    UniGene
    528087
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ITPKB
    GeneCards
    ITPKB