Cell Senescence Entries for ITPK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

ITPK1 Gene Information

HGNC symbol
ITPK1 
Aliases
 
Common name
inositol-tetrakisphosphate 1-kinase 
Entrez Id
3705
Description
This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016].

ITPK1 Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:32957; inositol trisphosphate metabolic process
GO:7165; signal transduction
GO:70266; necroptotic process
GO:7596; blood coagulation
GO:52746; inositol phosphorylation
GO:21915; neural tube development
Cellular component: GO:5829; cytosol
GO:16324; apical plasma membrane
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:16853; isomerase activity
GO:287; magnesium ion binding
GO:16787; hydrolase activity
GO:47325; inositol tetrakisphosphate 1-kinase activity
GO:52725; inositol-1,3,4-trisphosphate 6-kinase activity
GO:52726; inositol-1,3,4-trisphosphate 5-kinase activity
And 3 more GO terms
Show all GO terms

Homologs of ITPK1 in Model Organisms

Danio rerio
itpk1b
Danio rerio
itpk1a
Mus musculus
Itpk1
Rattus norvegicus
Itpk1

External links

OMIM
601838
Ensembl
ENSG00000100605
Entrez Gene
3705
UniGene
308122
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITPK1
GeneCards
ITPK1