Cell Senescence Entries for ITPK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    ITPK1 Gene Information

    HGNC symbol
    ITPK1 
    Aliases
    ITRPK1 
    Common name
    inositol-tetrakisphosphate 1-kinase 
    Entrez Id
    3705
    Description
    This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]

    ITPK1 Ontologies

    Gene Ontology
    Process:
    Cellular component:
    Function:
    Show all GO terms

    Homologs of ITPK1 in Model Organisms

    Danio rerio
    itpk1
    Mus musculus
    Itpk1
    Rattus norvegicus
    Itpk1

    External links

    OMIM
    601838
    Ensembl
    ENSG00000100605
    Entrez Gene
    3705
    UniGene
    308122
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ITPK1
    GeneCards
    ITPK1