Cell Senescence Entries for ITGB4

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
RNA interference of integrin beta4 (ITGB4) in vascular endothelial cells attenuated the senescence phenotype.
Primary Reference

    ITGB4 Gene Information

    HGNC symbol
    ITGB4 
    Aliases
    CD104; GP150 
    Common name
    integrin subunit beta 4 
    Entrez Id
    3691
    Description
    Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

    ITGB4 Ontologies

    Gene Ontology
    Process: GO:97186; amelogenesis
    GO:6914; autophagy
    GO:7155; cell adhesion
    GO:48870; cell motility
    GO:7160; cell-matrix adhesion
    GO:48565; digestive tract development
    GO:30198; extracellular matrix organization
    GO:31581; hemidesmosome assembly
    GO:7229; integrin-mediated signaling pathway
    GO:48333; mesodermal cell differentiation
    GO:35878; nail development
    And 4 more GO terms
    Cellular component: GO:30054; cell junction
    GO:31252; cell leading edge
    GO:9986; cell surface
    GO:70062; extracellular exosome
    GO:30056; hemidesmosome
    GO:8305; integrin complex
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:43235; receptor complex
    Function: GO:1664; G-protein coupled receptor binding
    GO:31994; insulin-like growth factor I binding
    GO:38132; neuregulin binding
    GO:5515; protein binding
    GO:4872; receptor activity
    Show all GO terms

    Homologs of ITGB4 in Model Organisms

    Danio rerio
    itgb4
    Mus musculus
    Itgb4
    Rattus norvegicus
    Itgb4

    External links

    OMIM
    147557
    Ensembl
    ENSG00000132470
    Entrez Gene
    3691
    UniGene
    632226
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ITGB4
    GeneCards
    ITGB4