Cell Senescence Entries for IRF3

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of IRF3 in foreskin fibroblasts (BJ cells) decreased cell growth and increased SA-beta-galactosidase activity by activating p53.
Primary Reference

    IRF3 Gene Information

    HGNC symbol
    IRF3 
    Aliases
    IIAE7 
    Common name
    interferon regulatory factor 3 
    Entrez Id
    3661
    Description
    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

    IRF3 Ontologies

    Gene Ontology
    Process:
    Cellular component:
    Function:
    Show all GO terms

    Homologs of IRF3 in Model Organisms

    Mus musculus
    Irf3
    Rattus norvegicus
    Irf3

    External links

    OMIM
    603734
    Ensembl
    ENSG00000126456
    Entrez Gene
    3661
    UniGene
    75254
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    IRF3
    GeneCards
    IRF3