Cell Senescence Entries for ING2

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Overexpression, Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of ING2 induced cellular senescence in young fibroblasts in a p53-dependent manner. In contrast, RNA interference of ING2 delayed the onset of senescence.
Primary Reference

    ING2 Gene Information

    HGNC symbol
    ING2 
    Aliases
    ING1L; p33ING2 
    Common name
    inhibitor of growth family member 2 
    Entrez Id
    3622
    Description
    This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

    ING2 Ontologies

    Gene Ontology
    Process: GO:16569; covalent chromatin modification
    GO:30317; flagellated sperm motility
    GO:48133; male germ-line stem cell asymmetric division
    GO:7141; male meiosis I
    GO:8285; negative regulation of cell proliferation
    GO:1902166; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
    GO:31065; positive regulation of histone deacetylation
    GO:45893; positive regulation of transcription, DNA-templated
    GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
    GO:2000772; regulation of cellular senescence
    GO:40008; regulation of growth
    And 8 more GO terms
    Cellular component: GO:16602; CCAAT-binding factor complex
    GO:5794; Golgi apparatus
    GO:16580; Sin3 complex
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:3677; DNA binding
    GO:3682; chromatin binding
    GO:35064; methylated histone binding
    GO:35091; phosphatidylinositol binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of ING2 in Model Organisms

    Danio rerio
    ing2
    Mus musculus
    Ing2
    Rattus norvegicus
    Ing2
    Saccharomyces cerevisiae
    YNG2

    External links

    OMIM
    604215
    Ensembl
    ENSG00000168556
    Entrez Gene
    3622
    UniGene
    107153
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ING2
    GeneCards
    ING2