Cell Senescence Entries for ING1

Cell Types
Foreskin fibroblast
Cell Lines
Hs68
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Fibroblasts overexpressing the ING1a isoform resulted in cell cycle arrest with cells displaying a senescent-like flattened morphology, an increase in SA-heterochromatin foci and increased SA-beta-galactosidase activity. In contrast, overexpressing the ING1b isoform induced nuclear changes characteristic to apoptosis.
Primary Reference

    ING1 Gene Information

    HGNC symbol
    ING1 
    Aliases
    p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a 
    Common name
    inhibitor of growth family member 1 
    Entrez Id
    3621
    Description
    This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

    ING1 Ontologies

    Gene Ontology
    Process: GO:7049; cell cycle
    GO:30308; negative regulation of cell growth
    GO:8285; negative regulation of cell proliferation
    GO:10941; regulation of cell death
    Cellular component: GO:5634; nucleus
    Function: GO:35064; methylated histone binding
    GO:5515; protein binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of ING1 in Model Organisms

    Danio rerio
    ing1
    Drosophila melanogaster
    CG7379
    Mus musculus
    Ing1
    Rattus norvegicus
    Ing1
    Schizosaccharomyces pombe
    png2

    External links

    OMIM
    601566
    Ensembl
    ENSG00000153487
    Entrez Gene
    3621
    UniGene
    46700
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ING1
    GeneCards
    ING1