Cell Senescence Entries for IL8

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
IMR-90, BJ, WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
RNA interference of the chemokine receptor CXCR2 (IL8) alleviated both replicative and oncogene-induced senescence and diminished the DNA-damage response. Conversely, ectopic expression of CXCR2 resulted in premature senescence via a p53-dependent mechanism.
Primary Reference

    IL8 Gene Information

    HGNC symbol
    IL8 
    Aliases
    IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1 
    Common name
    C-X-C motif chemokine ligand 8 
    Entrez Id
    3576
    Description
    The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

    CXCL8 Ontologies

    Gene Ontology
    Process: GO:7186; G-protein coupled receptor signaling pathway
    GO:36499; PERK-mediated unfolded protein response
    GO:1525; angiogenesis
    GO:19722; calcium-mediated signaling
    GO:7050; cell cycle arrest
    GO:44344; cellular response to fibroblast growth factor stimulus
    GO:71347; cellular response to interleukin-1
    GO:71222; cellular response to lipopolysaccharide
    GO:71356; cellular response to tumor necrosis factor
    GO:70098; chemokine-mediated signaling pathway
    GO:6935; chemotaxis
    And 20 more GO terms
    Cellular component: GO:5576; extracellular region
    GO:5615; extracellular space
    GO:5622; intracellular
    Function: GO:8009; chemokine activity
    GO:5153; interleukin-8 receptor binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of CXCL8 in Model Organisms

    No homologs found

    In other databases

    LongevityMap
    • This gene is present as CXCL8

    External links

    OMIM
    146930
    Ensembl
    ENSG00000169429
    Entrez Gene
    3576
    UniGene
    624
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    IL8
    GeneCards
    IL8