Cell Senescence Entries for IL1A

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Treatment of human endothelial cells with an antisense oligodeoxynucleotide of IL-1 alpha (IL1A) prevented cell senescence and extended the proliferative lifespan of cells.
Primary Reference

    IL1A Gene Information

    HGNC symbol
    IL1A 
    Aliases
    IL1; IL-1A; IL1F1; IL1-ALPHA 
    Common name
    interleukin 1 alpha 
    Entrez Id
    3552
    Description
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

    IL1A Ontologies

    Gene Ontology
    Process: GO:6915; apoptotic process
    GO:8283; cell proliferation
    GO:34605; cellular response to heat
    GO:2248; connective tissue replacement involved in inflammatory response wound healing
    GO:19221; cytokine-mediated signaling pathway
    GO:35234; ectopic germ cell programmed cell death
    GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
    GO:1660; fever generation
    GO:6955; immune response
    GO:6954; inflammatory response
    GO:70498; interleukin-1-mediated signaling pathway
    And 16 more GO terms
    Cellular component: GO:5829; cytosol
    GO:5576; extracellular region
    GO:5615; extracellular space
    Function: GO:5507; copper ion binding
    GO:5125; cytokine activity
    GO:5149; interleukin-1 receptor binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of IL1A in Model Organisms

    Mus musculus
    Il1a
    Rattus norvegicus
    Il1a

    In other databases

    LongevityMap
    • This gene is present as IL1A

    External links

    OMIM
    147760
    Ensembl
    ENSG00000115008
    Entrez Gene
    3552
    UniGene
    1722
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    IL1A
    GeneCards
    IL1A