Cell Senescence Entries for IGFBP3

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
RNA interference of IGFBP3 attenuated the premature senescence induced by sub lethal doses of tert-butylhydroperoxide or ethanol.
Primary Reference

    IGFBP3 Gene Information

    HGNC symbol
    IGFBP3 
    Aliases
    IBP3; BP-53 
    Common name
    insulin like growth factor binding protein 3 
    Entrez Id
    3486
    Description
    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

    IGFBP3 Ontologies

    Gene Ontology
    Process: GO:6915; apoptotic process
    GO:44267; cellular protein metabolic process
    GO:8285; negative regulation of cell proliferation
    GO:1933; negative regulation of protein phosphorylation
    GO:9968; negative regulation of signal transduction
    GO:14912; negative regulation of smooth muscle cell migration
    GO:48662; negative regulation of smooth muscle cell proliferation
    GO:1649; osteoblast differentiation
    GO:43410; positive regulation of MAPK cascade
    GO:43065; positive regulation of apoptotic process
    GO:43085; positive regulation of catalytic activity
    And 9 more GO terms
    Cellular component: GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:16942; insulin-like growth factor binding protein complex
    GO:42567; insulin-like growth factor ternary complex
    GO:5634; nucleus
    Function: GO:1968; fibronectin binding
    GO:31994; insulin-like growth factor I binding
    GO:31995; insulin-like growth factor II binding
    GO:5520; insulin-like growth factor binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:8160; protein tyrosine phosphatase activator activity
    Show all GO terms

    Homologs of IGFBP3 in Model Organisms

    Danio rerio
    igfbp3
    Mus musculus
    Igfbp3
    Rattus norvegicus
    Igfbp3

    In other databases

    GenAge human genes
    • This gene is present as IGFBP3
    LongevityMap
    • This gene is present as IGFBP3

    External links

    OMIM
    146732
    Ensembl
    ENSG00000146674
    Entrez Gene
    3486
    UniGene
    450230
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    IGFBP3
    GeneCards
    IGFBP3