Cell Senescence Entries for IGFBP1

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Transfection of IGFBP1 or addition of condition medium from IGFBP1-transfected cells to breast cancer cells (MCF-7) caused induction of several senescent phenotypes, including a decrease in cell proliferation, increase in G0/G1 cell cycle arrest cells, changes in cell morphology and increased SA-beta-galactosidase activity.
Primary Reference

    IGFBP1 Gene Information

    HGNC symbol
    IGFBP1 
    Aliases
    AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1 
    Common name
    insulin like growth factor binding protein 1 
    Entrez Id
    3484
    Description
    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

    IGFBP1 Ontologies

    Gene Ontology
    Process: GO:36499; PERK-mediated unfolded protein response
    GO:7568; aging
    GO:44267; cellular protein metabolic process
    GO:8286; insulin receptor signaling pathway
    GO:90090; negative regulation of canonical Wnt signaling pathway
    GO:30307; positive regulation of cell growth
    GO:43567; regulation of insulin-like growth factor receptor signaling pathway
    GO:7165; signal transduction
    GO:42246; tissue regeneration
    Cellular component: GO:5794; Golgi apparatus
    GO:5576; extracellular region
    GO:5615; extracellular space
    Function: GO:31994; insulin-like growth factor I binding
    GO:31995; insulin-like growth factor II binding
    GO:5520; insulin-like growth factor binding
    GO:5515; protein binding
    GO:5102; receptor binding
    Show all GO terms

    Homologs of IGFBP1 in Model Organisms

    Danio rerio
    igfbp1b
    Mus musculus
    Igfbp1
    Rattus norvegicus
    Igfbp1

    In other databases

    LongevityMap
    • This gene is present as IGFBP1

    External links

    OMIM
    146730
    Ensembl
    ENSG00000146678
    Entrez Gene
    3484
    UniGene
    642938
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    IGFBP1
    GeneCards
    IGFBP1