Cell Senescence Entries for IFNG

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
IFN-gamma (IFNG) treatment induced cellular senescence in umbilical vein endothelial cells (HUVECs), as confirmed by G0/G1 cell cycle arrest, up-regulation of p53 and p21 protein levels, increased SA-beta-galactosidase staining and the accumulation of SA-heterochromatin foci.
Primary Reference

    IFNG Gene Information

    HGNC symbol
    IFNG 
    Aliases
    IFG; IFI 
    Common name
    interferon gamma 
    Entrez Id
    3458
    Description
    This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

    IFNG Ontologies

    Gene Ontology
    Process: GO:2302; CD8-positive, alpha-beta T cell differentiation involved in immune response
    GO:50852; T cell receptor signaling pathway
    GO:2250; adaptive immune response
    GO:19882; antigen processing and presentation
    GO:6915; apoptotic process
    GO:7050; cell cycle arrest
    GO:7166; cell surface receptor signaling pathway
    GO:71351; cellular response to interleukin-18
    GO:71222; cellular response to lipopolysaccharide
    GO:42742; defense response to bacterium
    GO:42832; defense response to protozoan
    And 68 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:9897; external side of plasma membrane
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:43005; neuron projection
    GO:43204; perikaryon
    Function: GO:5125; cytokine activity
    GO:5133; interferon-gamma receptor binding
    Show all GO terms

    Homologs of IFNG in Model Organisms

    Danio rerio
    ifng1-2
    Mus musculus
    Ifng
    Rattus norvegicus
    Ifng

    In other databases

    LongevityMap
    • This gene is present as IFNG

    External links

    OMIM
    147570
    Ensembl
    ENSG00000111537
    Entrez Gene
    3458
    UniGene
    856
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    IFNG
    GeneCards
    IFNG