Cell Senescence Entries for ID4

Cell Types
Prostate cancer
Cell Lines
DU145
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
ID4 was found to promote cellular senescence in prostate cancer cells (DU145). Ectopic overexpression of ID4 in androgen receptor-negative DU145 cells resulted in increased expression of p16, p21, p27, E-cadherin and vimentin but down-regulated E2F1 expression. ID4 also potentiated the effect of doxorubicin induced senescence and apoptosis.
Primary Reference

    ID4 Gene Information

    HGNC symbol
    ID4 
    Aliases
    IDB4; bHLHb27 
    Common name
    inhibitor of DNA binding 4, HLH protein 
    Entrez Id
    3400
    Description
    This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]

    ID4 Ontologies

    Gene Ontology
    Process: GO:82; G1/S transition of mitotic cell cycle
    GO:34613; cellular protein localization
    GO:22010; central nervous system myelination
    GO:21895; cerebral cortex neuron differentiation
    GO:7623; circadian rhythm
    GO:45444; fat cell differentiation
    GO:21766; hippocampus development
    GO:48712; negative regulation of astrocyte differentiation
    GO:45599; negative regulation of fat cell differentiation
    GO:45665; negative regulation of neuron differentiation
    GO:48715; negative regulation of oligodendrocyte differentiation
    And 12 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5634; nucleus
    Function: GO:1085; RNA polymerase II transcription factor binding
    GO:5515; protein binding
    GO:46983; protein dimerization activity
    GO:3714; transcription corepressor activity
    Show all GO terms

    Homologs of ID4 in Model Organisms

    Danio rerio
    id4
    Mus musculus
    Id4
    Rattus norvegicus
    Id4

    External links

    OMIM
    600581
    Ensembl
    ENSG00000172201
    Entrez Gene
    3400
    UniGene
    519601
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ID4
    GeneCards
    ID4