Cell Senescence Entries for ID1

Cell Types
Dermal endothelial, Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Overexpression of ID1 delayed the onset of replicative senescence in human endothelial cells and resulted in increased replicative capacity correlated with low gene expression of senescence markers, p16, p21, and p27.
Primary Reference

    ID1 Gene Information

    HGNC symbol
    ID1 
    Aliases
    ID; bHLHb24 
    Common name
    inhibitor of DNA binding 1, HLH protein 
    Entrez Id
    3397
    Description
    The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

    ID1 Ontologies

    Gene Ontology
    Process: GO:30509; BMP signaling pathway
    GO:1525; angiogenesis
    GO:43534; blood vessel endothelial cell migration
    GO:48514; blood vessel morphogenesis
    GO:7420; brain development
    GO:36164; cell-abiotic substrate adhesion
    GO:1903351; cellular response to dopamine
    GO:71364; cellular response to epidermal growth factor stimulus
    GO:1990090; cellular response to nerve growth factor stimulus
    GO:1901653; cellular response to peptide
    GO:7623; circadian rhythm
    And 26 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:5813; centrosome
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:70628; proteasome binding
    GO:8022; protein C-terminus binding
    GO:47485; protein N-terminus binding
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    GO:43621; protein self-association
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8134; transcription factor binding
    Show all GO terms

    Homologs of ID1 in Model Organisms

    Danio rerio
    id1
    Mus musculus
    Id1
    Rattus norvegicus
    Id1

    External links

    OMIM
    600349
    Ensembl
    ENSG00000125968
    Entrez Gene
    3397
    UniGene
    504609
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ID1
    GeneCards
    ID1