Cell Senescence Entries for HSPA5

Cell Types
Ovarian cancer
Cell Lines
A2780
Cancer Cell?
Yes
Method
Overexpression, Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
Overexpression of GRP78 (HSPA5) protected cisplatin-sensitive ovarian cancer cells (A2780) from cisplatin-induced senescence through P53 and CDC2. Knockdown of GRP78 rescued the senescence sensitivity of cisplatin-resistant C13K cells to cisplatin through P21 and CDC2.
Primary Reference

    HSPA5 Gene Information

    HGNC symbol
    HSPA5 
    Aliases
    BIP; MIF2; GRP78; HEL-S-89n 
    Common name
    heat shock protein family A (Hsp70) member 5 
    Entrez Id
    3309
    Description
    The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

    HSPA5 Ontologies

    Gene Ontology
    Process: GO:36500; ATF6-mediated unfolded protein response
    GO:6983; ER overload response
    GO:36498; IRE1-mediated unfolded protein response
    GO:36499; PERK-mediated unfolded protein response
    GO:6987; activation of signaling protein activity involved in unfolded protein response
    GO:71236; cellular response to antibiotic
    GO:71320; cellular response to cAMP
    GO:71277; cellular response to calcium ion
    GO:35690; cellular response to drug
    GO:42149; cellular response to glucose starvation
    GO:71353; cellular response to interleukin-4
    And 28 more GO terms
    Cellular component: GO:8180; COP9 signalosome
    GO:9986; cell surface
    GO:5783; endoplasmic reticulum
    GO:34663; endoplasmic reticulum chaperone complex
    GO:5788; endoplasmic reticulum lumen
    GO:5789; endoplasmic reticulum membrane
    GO:5793; endoplasmic reticulum-Golgi intermediate compartment
    GO:70062; extracellular exosome
    GO:31012; extracellular matrix
    GO:5925; focal adhesion
    GO:30176; integral component of endoplasmic reticulum membrane
    And 9 more GO terms
    Function: GO:5524; ATP binding
    GO:16887; ATPase activity
    GO:45296; cadherin binding
    GO:5509; calcium ion binding
    GO:51087; chaperone binding
    GO:19899; enzyme binding
    GO:1948; glycoprotein binding
    GO:51787; misfolded protein binding
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:43022; ribosome binding
    And 3 more GO terms
    Show all GO terms

    Homologs of HSPA5 in Model Organisms

    Caenorhabditis elegans
    hsp-4
    Danio rerio
    hspa5
    Drosophila melanogaster
    Hsc70-3
    Mus musculus
    Hspa5
    Rattus norvegicus
    Hspa5
    Saccharomyces cerevisiae
    KAR2
    Schizosaccharomyces pombe
    bip1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as hsp-4
    • A homolog of this gene for Drosophila melanogaster is present as Hsc70-3
    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Hspa5

    External links

    OMIM
    138120
    Ensembl
    ENSG00000044574
    Entrez Gene
    3309
    UniGene
    743241
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HSPA5
    GeneCards
    HSPA5