Cell Senescence Entries for HMGB1

Cell Types
Melanoma, Lung cancer
Cell Lines
A375, G361, SK-MEL-28, NCI-H1299
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
HMGB1 known down in melanoma cells resulted in cell cycle arrest and senescence as shown by decreased BrdU incorporation and increased SA-beta-galactosidase activity. It was demonstrated that HMGB1 deficiency-induced inhibition of cell proliferation was mediated by p21, which was induced via a Sp1-dependent mechanism.
Primary Reference

    HMGB1 Gene Information

    HGNC symbol
    HMGB1 
    Aliases
    HMG1; HMG3; HMG-1; SBP-1 
    Common name
    high mobility group box 1 
    Entrez Id
    3146
    Description
    This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

    HMGB1 Ontologies

    Gene Ontology
    Process: GO:32392; DNA geometric change
    GO:51103; DNA ligation involved in DNA repair
    GO:6310; DNA recombination
    GO:6265; DNA topological change
    GO:35711; T-helper 1 cell activation
    GO:45063; T-helper 1 cell differentiation
    GO:33151; V(D)J recombination
    GO:2218; activation of innate immune response
    GO:6309; apoptotic DNA fragmentation
    GO:43277; apoptotic cell clearance
    GO:6914; autophagy
    And 40 more GO terms
    Cellular component: GO:9986; cell surface
    GO:793; condensed chromosome
    GO:5793; endoplasmic reticulum-Golgi intermediate compartment
    GO:5768; endosome
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:1904813; ficolin-1-rich granule lumen
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:34774; secretory granule lumen
    And 2 more GO terms
    Function: GO:19958; C-X-C chemokine binding
    GO:8301; DNA binding, bending
    GO:70182; DNA polymerase binding
    GO:50786; RAGE receptor binding
    GO:3723; RNA binding
    GO:405; bubble DNA binding
    GO:42056; chemoattractant activity
    GO:5125; cytokine activity
    GO:3684; damaged DNA binding
    GO:3690; double-stranded DNA binding
    GO:400; four-way junction DNA binding
    And 10 more GO terms
    Show all GO terms

    Homologs of HMGB1 in Model Organisms

    Mus musculus
    Hmgb1
    Rattus norvegicus
    LOC685520

    In other databases

    GenAge human genes
    • This gene is present as HMGB1
    LongevityMap
    • This gene is present as HMGB1

    External links

    OMIM
    163905
    Ensembl
    ENSG00000189403
    Entrez Gene
    3146
    UniGene
    434102
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HMGB1
    GeneCards
    HMGB1