Cell Senescence Entries for HK3

Cell Types
Lung fibroblast, Embryonic kidney
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    HK3 Gene Information

    HGNC symbol
    HK3 
    Aliases
    HXK3; HKIII 
    Common name
    hexokinase 3 
    Entrez Id
    3101
    Description
    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

    HK3 Ontologies

    Gene Ontology
    Process: GO:61621; canonical glycolysis
    GO:46835; carbohydrate phosphorylation
    GO:1678; cellular glucose homeostasis
    GO:51156; glucose 6-phosphate metabolic process
    GO:15758; glucose transport
    GO:6096; glycolytic process
    GO:43312; neutrophil degranulation
    Cellular component: GO:5829; cytosol
    GO:5576; extracellular region
    GO:1904813; ficolin-1-rich granule lumen
    GO:5739; mitochondrion
    GO:34774; secretory granule lumen
    Function: GO:5524; ATP binding
    GO:8865; fructokinase activity
    GO:4340; glucokinase activity
    GO:5536; glucose binding
    GO:4396; hexokinase activity
    GO:19158; mannokinase activity
    Show all GO terms

    Homologs of HK3 in Model Organisms

    Caenorhabditis elegans
    CELE_H25P06.1
    Mus musculus
    Hk3
    Rattus norvegicus
    Hk3

    External links

    OMIM
    142570
    Ensembl
    ENSG00000160883
    Entrez Gene
    3101
    UniGene
    411695
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HK3
    GeneCards
    HK3