Cell Senescence Entries for HIVEP1

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of MBP-1 (HIVEP1) in human foreskin fibroblasts resulted in an induction of premature senescence, accumulation of cells in the G1 phase, flattened cell morphology and increased SA-beta-galactosidase activity.
Primary Reference

    HIVEP1 Gene Information

    HGNC symbol
    HIVEP1 
    Aliases
    GAAP; ZAS1; CIRIP; MBP-1; ZNF40; CRYBP1; ZNF40A; PRDII-BF1; Schnurri-1 
    Common name
    human immunodeficiency virus type I enhancer binding protein 1 
    Entrez Id
    3096
    Description
    This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]

    HIVEP1 Ontologies

    Gene Ontology
    Process: GO:7275; multicellular organism development
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:7165; signal transduction
    GO:6366; transcription from RNA polymerase II promoter
    Cellular component: GO:5739; mitochondrion
    GO:16604; nuclear body
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:980; RNA polymerase II distal enhancer sequence-specific DNA binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    GO:44212; transcription regulatory region DNA binding
    GO:1206; transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
    Show all GO terms

    Homologs of HIVEP1 in Model Organisms

    Danio rerio
    hivep1
    Drosophila melanogaster
    shn
    Mus musculus
    Hivep1
    Rattus norvegicus
    Hivep1

    External links

    OMIM
    194540
    Ensembl
    ENSG00000095951
    Entrez Gene
    3096
    UniGene
    567284
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HIVEP1
    GeneCards
    HIVEP1