Cell Senescence Entries for HEPACAM

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
In breast cancer cells (MCF-7), stable transfection of HEPACAM, which is frequently downregulated in carcinomas, inhibited colony formation and cell proliferation, and lead to an increased number of cells which are arrested in the G(2)/M phase, have an enlarged morphology and display increased beta-galactosidase activity.
Primary Reference

    HEPACAM Gene Information

    HGNC symbol
    HEPACAM 
    Aliases
    MLC2A; MLC2B; GlialCAM 
    Common name
    hepatic and glial cell adhesion molecule 
    Entrez Id
    220296
    Description
    The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]

    HEPACAM Ontologies

    Gene Ontology
    Process: GO:7155; cell adhesion
    GO:7050; cell cycle arrest
    GO:34613; cellular protein localization
    GO:40008; regulation of growth
    Cellular component: GO:30424; axon
    GO:5911; cell-cell junction
    GO:5737; cytoplasm
    GO:16021; integral component of membrane
    Function:
    Show all GO terms

    Homologs of HEPACAM in Model Organisms

    Danio rerio
    LOC100333891
    Mus musculus
    Hepacam
    Rattus norvegicus
    Hepacam

    External links

    OMIM
    611642
    Ensembl
    ENSG00000165478
    Entrez Gene
    220296
    UniGene
    745294
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HEPACAM
    GeneCards
    HEPACAM