Cell Senescence Entries for HDAC4

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Overexpression, Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
The expression patterns of HDAC4 and Sirtuin 1 (SIRT1; the mammalian homolog of Sir2) were positively correlated during cellular senescence. Moreover, overexpression of HDAC4 delayed senescence, whereas knockdown of HDAC4 led to premature senescence in human fibroblasts.
Primary Reference

    HDAC4 Gene Information

    HGNC symbol
    HDAC4 
    Aliases
    HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A 
    Common name
    histone deacetylase 4 
    Entrez Id
    9759
    Description
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

    HDAC4 Ontologies

    Gene Ontology
    Process: GO:42113; B cell activation
    GO:30183; B cell differentiation
    GO:14898; cardiac muscle hypertrophy in response to stress
    GO:71260; cellular response to mechanical stimulus
    GO:71374; cellular response to parathyroid hormone stimulus
    GO:71356; cellular response to tumor necrosis factor
    GO:6338; chromatin remodeling
    GO:70932; histone H3 deacetylation
    GO:70933; histone H4 deacetylation
    GO:16575; histone deacetylation
    GO:6954; inflammatory response
    And 32 more GO terms
    Cellular component: GO:31672; A band
    GO:30018; Z disc
    GO:42641; actomyosin
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:118; histone deacetylase complex
    GO:31594; neuromuscular junction
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    GO:17053; transcriptional repressor complex
    And 1 more GO terms
    Function: GO:32041; NAD-dependent histone deacetylase activity (H3-K14 specific)
    GO:1025; RNA polymerase III transcription factor binding
    GO:33613; activating transcription factor binding
    GO:3682; chromatin binding
    GO:1047; core promoter binding
    GO:4407; histone deacetylase activity
    GO:42826; histone deacetylase binding
    GO:30955; potassium ion binding
    GO:5515; protein binding
    GO:33558; protein deacetylase activity
    GO:19901; protein kinase binding
    And 7 more GO terms
    Show all GO terms

    Homologs of HDAC4 in Model Organisms

    Danio rerio
    hdac4
    Drosophila melanogaster
    HDAC4
    Mus musculus
    Hdac4
    Rattus norvegicus
    Hdac4

    External links

    OMIM
    605314
    Ensembl
    ENSG00000068024
    Entrez Gene
    9759
    UniGene
    20516
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HDAC4
    GeneCards
    HDAC4