Cell Senescence Entries for HDAC1

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
HDAC1 overexpression led to senescence through both an accumulation of hypophosphorylated active retinoblastoma protein (pRb) and an increase in the level of protein phosphatase 2A catalytic subunit.
Primary Reference

    HDAC1 Gene Information

    HGNC symbol
    HDAC1 
    Aliases
    HD1; RPD3; GON-10; RPD3L1 
    Common name
    histone deacetylase 1 
    Entrez Id
    3065
    Description
    Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

    HDAC1 Ontologies

    Gene Ontology
    Process: GO:43044; ATP-dependent chromatin remodeling
    GO:1904837; beta-catenin-TCF complex assembly
    GO:7596; blood coagulation
    GO:6325; chromatin organization
    GO:6338; chromatin remodeling
    GO:32922; circadian regulation of gene expression
    GO:42733; embryonic digit morphogenesis
    GO:9913; epidermal cell differentiation
    GO:61029; eyelid development in camera-type eye
    GO:61198; fungiform papilla formation
    GO:60789; hair follicle placode formation
    And 22 more GO terms
    Cellular component: GO:16581; NuRD complex
    GO:16580; Sin3 complex
    GO:785; chromatin
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:118; histone deacetylase complex
    GO:790; nuclear chromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    Function: GO:32041; NAD-dependent histone deacetylase activity (H3-K14 specific)
    GO:51059; NF-kappaB binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:980; RNA polymerase II distal enhancer sequence-specific DNA binding
    GO:1103; RNA polymerase II repressing transcription factor binding
    GO:1106; RNA polymerase II transcription corepressor activity
    GO:1085; RNA polymerase II transcription factor binding
    GO:33613; activating transcription factor binding
    GO:1047; core promoter binding
    GO:1046; core promoter sequence-specific DNA binding
    GO:19213; deacetylase activity
    And 14 more GO terms
    Show all GO terms

    Homologs of HDAC1 in Model Organisms

    Danio rerio
    hdac1
    Drosophila melanogaster
    Rpd3
    Mus musculus
    Hdac1
    Rattus norvegicus
    Hdac1
    Saccharomyces cerevisiae
    RPD3

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
    • A homolog of this gene for Drosophila melanogaster is present as Rpd3
    GenAge human genes
    • This gene is present as HDAC1
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Rpd3
    • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3

    External links

    OMIM
    601241
    Ensembl
    ENSG00000116478
    Entrez Gene
    3065
    UniGene
    88556
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HDAC1
    GeneCards
    HDAC1