Cell Senescence Entries for GRK6

Cell Types
Lung fibroblast, Embryonic kidney
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    GRK6 Gene Information

    HGNC symbol
    GRK6 
    Aliases
    GPRK6 
    Common name
    G protein-coupled receptor kinase 6 
    Entrez Id
    2870
    Description
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

    GRK6 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:6468; protein phosphorylation
    GO:8277; regulation of G-protein coupled receptor protein signaling pathway
    Cellular component: GO:16020; membrane
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:4703; G-protein coupled receptor kinase activity
    GO:47696; beta-adrenergic receptor kinase activity
    GO:5515; protein binding
    Show all GO terms

    Homologs of GRK6 in Model Organisms

    Danio rerio
    grk6
    Mus musculus
    Grk6
    Rattus norvegicus
    Grk6

    External links

    OMIM
    600869
    Ensembl
    ENSG00000198055
    Entrez Gene
    2870
    UniGene
    235116
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    GRK6
    GeneCards
    GRK6