Cell Senescence Entries for GNG11

Cell Types
Lung fibroblast
Cell Lines
TIG-7
Cancer Cell?
No
Method
Overexpression, Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of GNG11 induced cellular senescence in normal human fibroblasts, with cells displaying enlarged, flattened morphology and increased SA-beta-galactosidase activity. In contrast, down-regulation by antisense cDNA extended cell lifespan.
Primary Reference

    GNG11 Gene Information

    HGNC symbol
    GNG11 
    Aliases
    GNGT11 
    Common name
    G protein subunit gamma 11 
    Entrez Id
    2791
    Description
    This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

    GNG11 Ontologies

    Gene Ontology
    Process: GO:7186; G-protein coupled receptor signaling pathway
    GO:71377; cellular response to glucagon stimulus
    GO:7165; signal transduction
    Cellular component: GO:5834; heterotrimeric G-protein complex
    GO:5886; plasma membrane
    Function: GO:3924; GTPase activity
    GO:4871; signal transducer activity
    Show all GO terms

    Homologs of GNG11 in Model Organisms

    Caenorhabditis elegans
    gpc-1
    Danio rerio
    gngt1
    Drosophila melanogaster
    Ggamma1
    Mus musculus
    Gng11
    Rattus norvegicus
    Gng11

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as gpc-1

    External links

    OMIM
    604390
    Ensembl
    ENSG00000127920
    Entrez Gene
    2791
    UniGene
    83381
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    GNG11
    GeneCards
    GNG11