Cell Senescence Entries for GLB1

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
GLB1, the gene encoding lysosomal beta-D-galactosidase, is responsible for the SA-beta-galactosidase activity in cellular senescence. RNA interference of GLB1 in late passage normal fibroblasts lead to senescence, however cells did not express an increase in SA-beta-galactosidase .
Primary Reference

    GLB1 Gene Information

    HGNC symbol
    GLB1 
    Aliases
    EBP; ELNR1; MPS4B 
    Common name
    galactosidase beta 1 
    Entrez Id
    2720
    Description
    This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. Mutations in this gene may result in GM1-gangliosidosis and Morquio B syndrome. [provided by RefSeq, Nov 2015]

    GLB1 Ontologies

    Gene Ontology
    Process: GO:44262; cellular carbohydrate metabolic process
    GO:19388; galactose catabolic process
    GO:6027; glycosaminoglycan catabolic process
    GO:6687; glycosphingolipid metabolic process
    GO:42340; keratan sulfate catabolic process
    GO:43312; neutrophil degranulation
    Cellular component: GO:5794; Golgi apparatus
    GO:35578; azurophil granule lumen
    GO:5737; cytoplasm
    GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:1904813; ficolin-1-rich granule lumen
    GO:43231; intracellular membrane-bounded organelle
    GO:43202; lysosomal lumen
    GO:48471; perinuclear region of cytoplasm
    GO:5773; vacuole
    And 1 more GO terms
    Function: GO:4565; beta-galactosidase activity
    GO:4308; exo-alpha-sialidase activity
    GO:16936; galactoside binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of GLB1 in Model Organisms

    Danio rerio
    glb1
    Mus musculus
    Glb1
    Rattus norvegicus
    Glb1

    External links

    OMIM
    611458
    Ensembl
    ENSG00000170266
    Entrez Gene
    2720
    UniGene
    443031
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    GLB1
    GeneCards
    GLB1