Cell Senescence Entries for GKN1

Cell Types
Gastric cancer
Cell Lines
AGS, MKN1
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
GKN1 overexpression was shown to trigger senescence, followed by apoptosis via up-regulation of the p53, p21, p27, and p16 proteins and down-regulation Skp2. Telomere length in 35 gastric cancers was shortened significantly compared with the corresponding gastric mucosae. GKN1 expression was found to be inversely correlated with telomere length and c-myc and hTERT mRNA expression, these normally act to inhibit senescence.
Primary Reference

    GKN1 Gene Information

    HGNC symbol
    GKN1 
    Aliases
    FOV; CA11; AMP18; BRICD1; foveolin 
    Common name
    gastrokine 1 
    Entrez Id
    56287
    Description
    The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]

    GKN1 Ontologies

    Gene Ontology
    Process: GO:7586; digestion
    GO:51781; positive regulation of cell division
    GO:42127; regulation of cell proliferation
    Cellular component: GO:5575; cellular_component
    GO:5615; extracellular space
    Function: GO:3674; molecular_function
    Show all GO terms

    Homologs of GKN1 in Model Organisms

    Mus musculus
    Gkn1
    Rattus norvegicus
    Gkn1

    External links

    OMIM
    606402
    Ensembl
    ENSG00000169605
    Entrez Gene
    56287
    UniGene
    69319
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    GKN1
    GeneCards
    GKN1