Cell Senescence Entries for GATA4

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
IMR-90, BJ
Cancer Cell?
No
Method
Overexpression, Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Promotes
Observations
Expression of GATA4 induced senescence in human diploid fibroblasts (BJ and IMR-90). These displayed increased SA-beta-galactosidase activity and decreased BrdU incorporation. Depletion of GATA4 partially decreased ionising radiation (IR) induced SA-beta-Gal activity and delayed replicative senescence. GATA4 acts through NF-kappaB to initiate the SASP dependant on activation by ATM and ATR and independent of p53 or p16 signalling.
Primary Reference

    GATA4 Gene Information

    HGNC symbol
    GATA4 
    Aliases
    TOF; ASD2; VSD1; TACHD 
    Common name
    GATA binding protein 4 
    Entrez Id
    2626
    Description
    This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

    GATA4 Ontologies

    Gene Ontology
    Process: GO:60413; atrial septum morphogenesis
    GO:3289; atrial septum primum morphogenesis
    GO:3290; atrial septum secundum morphogenesis
    GO:7596; blood coagulation
    GO:3215; cardiac right ventricle morphogenesis
    GO:3208; cardiac ventricle morphogenesis
    GO:61049; cell growth involved in cardiac muscle cell development
    GO:7267; cell-cell signaling
    GO:71333; cellular response to glucose stimulus
    GO:48617; embryonic foregut morphogenesis
    GO:35054; embryonic heart tube anterior/posterior pattern specification
    And 21 more GO terms
    Cellular component: GO:90575; RNA polymerase II transcription factor complex
    GO:16604; nuclear body
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:51525; NFAT protein binding
    GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:1085; RNA polymerase II transcription factor binding
    GO:33613; activating transcription factor binding
    GO:3682; chromatin binding
    GO:70410; co-SMAD binding
    GO:1158; enhancer sequence-specific DNA binding
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:43565; sequence-specific DNA binding
    And 8 more GO terms
    Show all GO terms

    Homologs of GATA4 in Model Organisms

    Danio rerio
    gata4
    Mus musculus
    Gata4
    Rattus norvegicus
    Gata4

    In other databases

    LongevityMap
    • This gene is present as GATA4

    External links

    OMIM
    600576
    Ensembl
    ENSG00000136574
    Entrez Gene
    2626
    UniGene
    243987
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    GATA4
    GeneCards
    GATA4