Cell Senescence Entries for FOXM1

Cell Types
Gallbladder cancer
Cell Lines
GBC-SD
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
SA-beta-galactosidase staining showed that down-regulation of FOXM1 could induce more senescent gallbladder cancer cells (P < 0.05).
Primary Reference

    FOXM1 Gene Information

    HGNC symbol
    FOXM1 
    Aliases
    MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2 
    Common name
    forkhead box M1 
    Entrez Id
    2305
    Description
    The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

    FOXM1 Ontologies

    Gene Ontology
    Process: GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    GO:6281; DNA repair
    GO:86; G2/M transition of mitotic cell cycle
    GO:90344; negative regulation of cell aging
    GO:32873; negative regulation of stress-activated MAPK cascade
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:45892; negative regulation of transcription, DNA-templated
    GO:8284; positive regulation of cell proliferation
    GO:2000781; positive regulation of double-strand break repair
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:45893; positive regulation of transcription, DNA-templated
    And 6 more GO terms
    Cellular component: GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:43565; sequence-specific DNA binding
    Show all GO terms

    Homologs of FOXM1 in Model Organisms

    Danio rerio
    foxm1
    Mus musculus
    Foxm1
    Rattus norvegicus
    Foxm1

    In other databases

    GenAge human genes
    • This gene is present as FOXM1

    External links

    OMIM
    602341
    Ensembl
    ENSG00000111206
    Entrez Gene
    2305
    UniGene
    239
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    FOXM1
    GeneCards
    FOXM1