Cell Senescence Entries for FOS

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Transient activation of c-fos (FOS) stimulated DNA synthesis in pre-senescent cells prolonging their proliferative lifespan.
Primary Reference

    FOS Gene Information

    HGNC symbol
    FOS 
    Aliases
    p55; AP-1; C-FOS 
    Common name
    Fos proto-oncogene, AP-1 transcription factor subunit 
    Entrez Id
    2353
    Description
    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

    FOS Ontologies

    Gene Ontology
    Process: GO:6306; DNA methylation
    GO:38095; Fc-epsilon receptor signaling pathway
    GO:60395; SMAD protein signal transduction
    GO:7568; aging
    GO:71276; cellular response to cadmium ion
    GO:71277; cellular response to calcium ion
    GO:31668; cellular response to extracellular stimulus
    GO:32870; cellular response to hormone stimulus
    GO:34614; cellular response to reactive oxygen species
    GO:1661; conditioned taste aversion
    GO:7565; female pregnancy
    And 25 more GO terms
    Cellular component: GO:5829; cytosol
    GO:5783; endoplasmic reticulum
    GO:16020; membrane
    GO:43005; neuron projection
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:32993; protein-DNA complex
    GO:35976; transcription factor AP-1 complex
    Function: GO:70412; R-SMAD binding
    GO:1102; RNA polymerase II activating transcription factor binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:979; RNA polymerase II core promoter sequence-specific DNA binding
    GO:3682; chromatin binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8134; transcription factor binding
    GO:44212; transcription regulatory region DNA binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    And 2 more GO terms
    Show all GO terms

    Homologs of FOS in Model Organisms

    Danio rerio
    fos
    Mus musculus
    Fos
    Rattus norvegicus
    Fos

    In other databases

    GenAge human genes
    • This gene is present as FOS

    External links

    OMIM
    164810
    Ensembl
    ENSG00000170345
    Entrez Gene
    2353
    UniGene
    25647
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    FOS
    GeneCards
    FOS