Cell Senescence Entries for FBXO31

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Ectopic expression of FBXO31 in breast cancer cells (MCF-7) induced cellular senescence, as indicated by an increase in SA-beta-galactosidase activity and a large flattened cell morphology.
Primary Reference

    FBXO31 Gene Information

    HGNC symbol
    FBXO31 
    Aliases
    FBX14; Fbx31; MRT45; FBXO14; pp2386 
    Common name
    F-box protein 31 
    Entrez Id
    79791
    Description
    This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

    FBXO31 Ontologies

    Gene Ontology
    Process: GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
    GO:31145; anaphase-promoting complex-dependent catabolic process
    GO:6974; cellular response to DNA damage stimulus
    GO:31571; mitotic G1 DNA damage checkpoint
    GO:50775; positive regulation of dendrite morphogenesis
    GO:2001224; positive regulation of neuron migration
    GO:209; protein polyubiquitination
    Cellular component: GO:19005; SCF ubiquitin ligase complex
    GO:5813; centrosome
    GO:5829; cytosol
    GO:43025; neuronal cell body
    Function: GO:30332; cyclin binding
    GO:4842; ubiquitin-protein transferase activity
    Show all GO terms

    Homologs of FBXO31 in Model Organisms

    Danio rerio
    si:ch211-147k9.7
    Mus musculus
    Fbxo31
    Rattus norvegicus
    Fbxo31

    External links

    OMIM
    609102
    Ensembl
    ENSG00000103264
    Entrez Gene
    79791
    UniGene
    567582
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    FBXO31
    GeneCards
    FBXO31