Cell Senescence Entries for FASTK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    FASTK Gene Information

    HGNC symbol
    FASTK 
    Aliases
    FAST 
    Common name
    Fas activated serine/threonine kinase 
    Entrez Id
    10922
    Description
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

    FASTK Ontologies

    Gene Ontology
    Process: GO:97190; apoptotic signaling pathway
    GO:6468; protein phosphorylation
    GO:43484; regulation of RNA splicing
    Cellular component: GO:5759; mitochondrial matrix
    Function: GO:5524; ATP binding
    GO:33867; Fas-activated serine/threonine kinase activity
    GO:3723; RNA binding
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of FASTK in Model Organisms

    Danio rerio
    fastk
    Mus musculus
    Fastk
    Rattus norvegicus
    Fastk

    External links

    OMIM
    606965
    Ensembl
    ENSG00000164896
    Entrez Gene
    10922
    UniGene
    647094
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    FASTK
    GeneCards
    FASTK