Cell Senescence Entries for EZH2

Cell Types
Gastric cancer
Cell Lines
SGC-7901
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
EZH2 depletion promoted senescence in human gastric cancer cells (SGC-7901). EZH2 depletion inhibited cell proliferation, caused cell cycle arrest, restored features of a cellular senescence phenotype and promoted doxorubicin-induced senescence.
Primary Reference

    EZH2 Gene Information

    HGNC symbol
    EZH2 
    Aliases
    WVS; ENX1; EZH1; KMT6; WVS2; ENX-1; EZH2b; KMT6A 
    Common name
    enhancer of zeste 2 polycomb repressive complex 2 subunit 
    Entrez Id
    2146
    Description
    This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

    EZH2 Ontologies

    Gene Ontology
    Process: GO:6306; DNA methylation
    GO:70314; G1 to G0 transition
    GO:14898; cardiac muscle hypertrophy in response to stress
    GO:70301; cellular response to hydrogen peroxide
    GO:35984; cellular response to trichostatin A
    GO:21695; cerebellar cortex development
    GO:6325; chromatin organization
    GO:36333; hepatocyte homeostasis
    GO:21766; hippocampus development
    GO:70734; histone H3-K27 methylation
    GO:98532; histone H3-K27 trimethylation
    And 27 more GO terms
    Cellular component: GO:35098; ESC/E(Z) complex
    GO:5737; cytoplasm
    GO:790; nuclear chromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:45120; pronucleus
    Function: GO:3677; DNA binding
    GO:979; RNA polymerase II core promoter sequence-specific DNA binding
    GO:31490; chromatin DNA binding
    GO:3682; chromatin binding
    GO:1047; core promoter binding
    GO:42054; histone methyltransferase activity
    GO:46976; histone methyltransferase activity (H3-K27 specific)
    GO:18024; histone-lysine N-methyltransferase activity
    GO:70878; primary miRNA binding
    GO:1990841; promoter-specific chromatin binding
    GO:5515; protein binding
    And 3 more GO terms
    Show all GO terms

    Homologs of EZH2 in Model Organisms

    Danio rerio
    ezh2
    Mus musculus
    Ezh2
    Rattus norvegicus
    Ezh2

    External links

    OMIM
    601573
    Ensembl
    ENSG00000106462
    Entrez Gene
    2146
    UniGene
    444082
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    EZH2
    GeneCards
    EZH2