Cell Senescence Entries for EWSR1

Cell Types
Hematopoietic stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Deletion of EWS (EWSR1) resulted in the early onset of senescence in hematopoietic stem progenitor cells. This was also accompanied by an increase in SA-beta-galactosidase activity and an induction in p16 expression.
Primary Reference

    EWSR1 Gene Information

    HGNC symbol
    EWSR1 
    Aliases
    EWS; EWS-FLI1; bK984G1.4 
    Common name
    EWS RNA binding protein 1 
    Entrez Id
    2130
    Description
    This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

    EWSR1 Ontologies

    Gene Ontology
    Process: GO:6355; regulation of transcription, DNA-templated
    GO:6351; transcription, DNA-templated
    Cellular component: GO:5737; cytoplasm
    GO:5730; nucleolus
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:3723; RNA binding
    GO:5516; calmodulin binding
    GO:42802; identical protein binding
    GO:5515; protein binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of EWSR1 in Model Organisms

    Danio rerio
    ewsr1b
    Mus musculus
    Ewsr1
    Rattus norvegicus
    Ewsr1

    External links

    OMIM
    133450
    Ensembl
    ENSG00000182944
    Entrez Gene
    2130
    UniGene
    374477
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    EWSR1
    GeneCards
    EWSR1