Cell Senescence Entries for ETS2

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
TIG-3, Hs68
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Overexpression of ETS2 leads to an accelerated oncogene-induced senescence, with increased levels of p16 and increased SA-beta-galactosidase activity.
Primary Reference

    ETS2 Gene Information

    HGNC symbol
    ETS2 
    Aliases
    ETS2IT1 
    Common name
    ETS proto-oncogene 2, transcription factor 
    Entrez Id
    2114
    Description
    This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

    ETS2 Ontologies

    Gene Ontology
    Process: GO:30154; cell differentiation
    GO:1712; ectodermal cell fate commitment
    GO:7498; mesoderm development
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:45893; positive regulation of transcription, DNA-templated
    GO:90009; primitive streak formation
    GO:1501; skeletal system development
    GO:6351; transcription, DNA-templated
    Cellular component: GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:3677; DNA binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:35259; glucocorticoid receptor binding
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:1078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of ETS2 in Model Organisms

    Danio rerio
    ets2
    Drosophila melanogaster
    pnt
    Mus musculus
    Ets2
    Rattus norvegicus
    Ets2

    External links

    OMIM
    164740
    Ensembl
    ENSG00000157557
    Entrez Gene
    2114
    UniGene
    644231
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ETS2
    GeneCards
    ETS2