Cell Senescence Entries for ETS1
- Cell Types
- Foreskin fibroblast, Lung fibroblast
- Cell Lines
- Hs68, TIG-3
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Promotes
- Observations
- Overexpression of ETS1 leads to an accelerated oncogene-induced senescence, with increased levels of p16 and increased SA-beta-galactosidase activity.
- Primary Reference
ETS1 Gene Information
- HGNC symbol
- ETS1
- Aliases
- p54; ETS-1; EWSR2; c-ets-1
- Common name
- ETS proto-oncogene 1, transcription factor
- Entrez Id
- 2113
- Description
- This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
ETS1 Ontologies
- Gene Ontology
-
Process: GO:30578; PML body organization
GO:60055; angiogenesis involved in wound healing
GO:48870; cell motility
GO:70301; cellular response to hydrogen peroxide
GO:44849; estrous cycle
GO:7565; female pregnancy
GO:21854; hypothalamus development
GO:6955; immune response
GO:8285; negative regulation of cell proliferation
GO:50728; negative regulation of inflammatory response
GO:21983; pituitary gland development
And 18 more GO terms Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5634; nucleus
GO:5667; transcription factor complex
Function: GO:3677; DNA binding
GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:35035; histone acetyltransferase binding
GO:42802; identical protein binding
GO:5515; protein binding
GO:982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:3700; transcription factor activity, sequence-specific DNA binding
GO:8134; transcription factor binding
GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Homologs of ETS1 in Model Organisms
External links
- OMIM
- 164720
- Ensembl
- ENSG00000134954
- Entrez Gene
- 2113
- UniGene
- 369438
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ETS1
- GeneCards
- ETS1