Cell Senescence Entries for ETS1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
Hs68, TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Overexpression of ETS1 leads to an accelerated oncogene-induced senescence, with increased levels of p16 and increased SA-beta-galactosidase activity.
Primary Reference

    ETS1 Gene Information

    HGNC symbol
    ETS1 
    Aliases
    p54; ETS-1; EWSR2; c-ets-1 
    Common name
    ETS proto-oncogene 1, transcription factor 
    Entrez Id
    2113
    Description
    This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

    ETS1 Ontologies

    Gene Ontology
    Process: GO:30578; PML body organization
    GO:60055; angiogenesis involved in wound healing
    GO:48870; cell motility
    GO:70301; cellular response to hydrogen peroxide
    GO:44849; estrous cycle
    GO:7565; female pregnancy
    GO:21854; hypothalamus development
    GO:6955; immune response
    GO:8285; negative regulation of cell proliferation
    GO:50728; negative regulation of inflammatory response
    GO:21983; pituitary gland development
    And 18 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5667; transcription factor complex
    Function: GO:3677; DNA binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:35035; histone acetyltransferase binding
    GO:42802; identical protein binding
    GO:5515; protein binding
    GO:982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8134; transcription factor binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of ETS1 in Model Organisms

    Mus musculus
    Ets1
    Rattus norvegicus
    Ets1

    External links

    OMIM
    164720
    Ensembl
    ENSG00000134954
    Entrez Gene
    2113
    UniGene
    369438
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ETS1
    GeneCards
    ETS1