Cell Senescence Entries for E2F1

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Constitutive expression of E2F1 in normal human fibroblasts arrested cell proliferation and induced a senescent phenotype, including flat morphology, increased SA-beta-galactosidase activity and increased expression of several markers of replicative senescence.
Primary Reference

    E2F1 Gene Information

    HGNC symbol
    E2F1 
    Aliases
    RBP3; E2F-1; RBAP1; RBBP3 
    Common name
    E2F transcription factor 1 
    Entrez Id
    1869
    Description
    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

    E2F1 Ontologies

    Gene Ontology
    Process: GO:77; DNA damage checkpoint
    GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:43276; anoikis
    GO:71398; cellular response to fatty acid
    GO:71456; cellular response to hypoxia
    GO:1990090; cellular response to nerve growth factor stimulus
    GO:71466; cellular response to xenobiotic stimulus
    GO:30900; forebrain development
    GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
    GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
    GO:1990086; lens fiber cell apoptotic process
    And 17 more GO terms
    Cellular component: GO:35189; Rb-E2F complex
    GO:5813; centrosome
    GO:5739; mitochondrion
    GO:790; nuclear chromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:1047; core promoter binding
    GO:5515; protein binding
    GO:46983; protein dimerization activity
    GO:19901; protein kinase binding
    GO:43565; sequence-specific DNA binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8134; transcription factor binding
    Show all GO terms

    Homologs of E2F1 in Model Organisms

    Danio rerio
    uncharacterized_H9GY
    Mus musculus
    E2f1

    In other databases

    GenAge human genes
    • This gene is present as E2F1

    External links

    OMIM
    189971
    Ensembl
    ENSG00000101412
    Entrez Gene
    1869
    UniGene
    654393
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    E2F1
    GeneCards
    E2F1