Cell Senescence Entries for DUSP3

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of VHR (DUSP3) lead to cell arrest at the G1-S and G2-M transitions. Cells displayed signs of cellular senescence, such as flattening, spreading, appearance of autophagosomes, SA-beta-galactosidase staining and decreased telomerase activity, as well as upregulation of p21 and downregulation of genes for cell-cycle regulators, DNA replication, transcription and mRNA processing.
Primary Reference

    DUSP3 Gene Information

    HGNC symbol
    DUSP3 
    Aliases
    VHR 
    Common name
    dual specificity phosphatase 3 
    Entrez Id
    1845
    Description
    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

    DUSP3 Ontologies

    Gene Ontology
    Process: GO:16311; dephosphorylation
    GO:1701; in utero embryonic development
    GO:188; inactivation of MAPK activity
    GO:70373; negative regulation of ERK1 and ERK2 cascade
    GO:46329; negative regulation of JNK cascade
    GO:43409; negative regulation of MAPK cascade
    GO:50868; negative regulation of T cell activation
    GO:50860; negative regulation of T cell receptor signaling pathway
    GO:35335; peptidyl-tyrosine dephosphorylation
    GO:45931; positive regulation of mitotic cell cycle
    Cellular component: GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:1772; immunological synapse
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:33549; MAP kinase phosphatase activity
    GO:16791; phosphatase activity
    GO:19901; protein kinase binding
    GO:4725; protein tyrosine phosphatase activity
    GO:8138; protein tyrosine/serine/threonine phosphatase activity
    Show all GO terms

    Homologs of DUSP3 in Model Organisms

    Danio rerio
    CR932037.1
    Mus musculus
    Dusp3
    Rattus norvegicus
    Dusp3

    External links

    OMIM
    600183
    Ensembl
    ENSG00000108861
    Entrez Gene
    1845
    UniGene
    181046
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    DUSP3
    GeneCards
    DUSP3