Cell Senescence Entries for DUSP16

Cell Types
Embryonic kidney, Liver cancer
Cell Lines
HepG2, PLC/PRF/5, HEK293FT
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
DUSP16 knockdown led to a G1/S transition arrest, reduced incorporation of BrdU, enhanced SA-beta-galactosidase activity and formation of SA-heterochromatin foci.
Primary Reference

    DUSP16 Gene Information

    HGNC symbol
    DUSP16 
    Aliases
    MKP7; MKP-7 
    Common name
    dual specificity phosphatase 16 
    Entrez Id
    80824
    Description
    This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

    DUSP16 Ontologies

    Gene Ontology
    Process: GO:45204; MAPK export from nucleus
    GO:45209; MAPK phosphatase export from nucleus, leptomycin B sensitive
    GO:16311; dephosphorylation
    GO:188; inactivation of MAPK activity
    GO:35335; peptidyl-tyrosine dephosphorylation
    Cellular component: GO:5737; cytoplasm
    GO:31410; cytoplasmic vesicle
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:17017; MAP kinase tyrosine/serine/threonine phosphatase activity
    GO:16791; phosphatase activity
    GO:4721; phosphoprotein phosphatase activity
    GO:4725; protein tyrosine phosphatase activity
    Show all GO terms

    Homologs of DUSP16 in Model Organisms

    Caenorhabditis elegans
    vhp-1
    Danio rerio
    dusp16
    Drosophila melanogaster
    puc
    Mus musculus
    Dusp16
    Rattus norvegicus
    Dusp16

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as puc

    External links

    OMIM
    607175
    Ensembl
    ENSG00000111266
    Entrez Gene
    80824
    UniGene
    536535
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    DUSP16
    GeneCards
    DUSP16