Cell Senescence Entries for DPY30

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Following depletion of DPY30, cells showed a severe proliferation defect and displayed a senescent phenotype, including a flattened and enlarged morphology, elevated level of reactive oxygen species (ROS), increased SA-beta-galactosidase activity and formation of SA-heterochromatin foci.
Primary Reference

    DPY30 Gene Information

    HGNC symbol
    DPY30 
    Aliases
    Cps25; Saf19; HDPY-30 
    Common name
    dpy-30, histone methyltransferase complex regulatory subunit 
    Entrez Id
    84661
    Description
    This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]

    DPY30 Ontologies

    Gene Ontology
    Process: GO:6348; chromatin silencing at telomere
    GO:16197; endosomal transport
    GO:51568; histone H3-K4 methylation
    GO:6351; transcription, DNA-templated
    Cellular component: GO:5794; Golgi apparatus
    GO:44666; MLL3/4 complex
    GO:48188; Set1C/COMPASS complex
    GO:781; chromosome, telomeric region
    GO:35097; histone methyltransferase complex
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5802; trans-Golgi network
    Function: GO:42800; histone methyltransferase activity (H3-K4 specific)
    GO:18024; histone-lysine N-methyltransferase activity
    GO:42802; identical protein binding
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    Show all GO terms

    Homologs of DPY30 in Model Organisms

    Danio rerio
    dpy30
    Drosophila melanogaster
    Dpy-30L2
    Mus musculus
    Dpy30
    Rattus norvegicus
    Dpy30

    External links

    OMIM
    612032
    Ensembl
    ENSG00000162961
    Entrez Gene
    84661
    UniGene
    531788
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    DPY30
    GeneCards
    DPY30