Cell Senescence Entries for DLX2

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
DLX2 expression led to increased cellular replicative lifespan in foreskin and lung fibroblasts. DLX2 expression reduced the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK (phosphatidylinositol 3-kinase-related kinase) kinase family.
Primary Reference

    DLX2 Gene Information

    HGNC symbol
    DLX2 
    Aliases
    TES1; TES-1 
    Common name
    distal-less homeobox 2 
    Entrez Id
    1746
    Description
    Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]

    DLX2 Ontologies

    Gene Ontology
    Process: GO:7420; brain development
    GO:48755; branching morphogenesis of a nerve
    GO:51216; cartilage development
    GO:21893; cerebral cortex GABAergic interneuron fate commitment
    GO:48701; embryonic cranial skeleton morphogenesis
    GO:21766; hippocampus development
    GO:45746; negative regulation of Notch signaling pathway
    GO:48715; negative regulation of oligodendrocyte differentiation
    GO:46533; negative regulation of photoreceptor cell differentiation
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:42475; odontogenesis of dentin-containing tooth
    And 9 more GO terms
    Cellular component: GO:5634; nucleus
    Function: GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:3682; chromatin binding
    GO:5515; protein binding
    GO:3727; single-stranded RNA binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:1228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
    Show all GO terms

    Homologs of DLX2 in Model Organisms

    Danio rerio
    dlx2b
    Mus musculus
    Dlx2

    External links

    OMIM
    126255
    Ensembl
    ENSG00000115844
    Entrez Gene
    1746
    UniGene
    419
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    DLX2
    GeneCards
    DLX2