Cell Senescence Entries for DHCR24

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Mutation
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
RNA interference of Seladin-1 (DHCR24) in human fibroblasts caused cells to bypass Ras-induced senescence, continue to proliferate, exhibit a normal cell morphology, reduce SA-beta-galactosidase activity, and to possess a higher tumorigenic potential.
Primary Reference

    DHCR24 Gene Information

    HGNC symbol
    DHCR24 
    Aliases
    DCE; SELADIN1; Nbla03646; seladin-1 
    Common name
    24-dehydrocholesterol reductase 
    Entrez Id
    1718
    Description
    This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]

    DHCR24 Ontologies

    Gene Ontology
    Process: GO:7265; Ras protein signal transduction
    GO:42987; amyloid precursor protein catabolic process
    GO:6915; apoptotic process
    GO:7050; cell cycle arrest
    GO:6695; cholesterol biosynthetic process
    GO:33489; cholesterol biosynthetic process via desmosterol
    GO:33490; cholesterol biosynthetic process via lathosterol
    GO:30539; male genitalia development
    GO:61024; membrane organization
    GO:43066; negative regulation of apoptotic process
    GO:8285; negative regulation of cell proliferation
    And 10 more GO terms
    Cellular component: GO:139; Golgi membrane
    GO:5856; cytoskeleton
    GO:5829; cytosol
    GO:5783; endoplasmic reticulum
    GO:5789; endoplasmic reticulum membrane
    GO:16021; integral component of membrane
    GO:16020; membrane
    GO:5634; nucleus
    Function: GO:246; delta24(24-1) sterol reductase activity
    GO:50614; delta24-sterol reductase activity
    GO:19899; enzyme binding
    GO:50660; flavin adenine dinucleotide binding
    GO:16614; oxidoreductase activity, acting on CH-OH group of donors
    GO:16628; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
    GO:42605; peptide antigen binding
    Show all GO terms

    Homologs of DHCR24 in Model Organisms

    Caenorhabditis elegans
    F52H2.6
    Danio rerio
    dhcr24
    Mus musculus
    Dhcr24
    Rattus norvegicus
    Dhcr24

    External links

    OMIM
    606418
    Ensembl
    ENSG00000116133
    Entrez Gene
    1718
    UniGene
    498727
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    DHCR24
    GeneCards
    DHCR24