Cell Senescence Entries for DEK

Cell Types
Foreskin keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Ectopic expression of DEK extended the cellular lifespan of keratinocytes.
Primary Reference

    DEK Gene Information

    HGNC symbol
    DEK 
    Aliases
    D6S231E 
    Common name
    DEK proto-oncogene 
    Entrez Id
    7913
    Description
    This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

    DEK Ontologies

    Gene Ontology
    Process: GO:6338; chromatin remodeling
    GO:16569; covalent chromatin modification
    GO:45815; positive regulation of gene expression, epigenetic
    GO:2000779; regulation of double-strand break repair
    GO:2001032; regulation of double-strand break repair via nonhomologous end joining
    GO:6357; regulation of transcription from RNA polymerase II promoter
    GO:7165; signal transduction
    GO:6366; transcription from RNA polymerase II promoter
    GO:19079; viral genome replication
    Cellular component: GO:43292; contractile fiber
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:3723; RNA binding
    GO:3682; chromatin binding
    GO:42393; histone binding
    Show all GO terms

    Homologs of DEK in Model Organisms

    Danio rerio
    dek
    Mus musculus
    Dek
    Rattus norvegicus
    Dek

    External links

    OMIM
    125264
    Ensembl
    ENSG00000124795
    Entrez Gene
    7913
    UniGene
    484813
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    DEK
    GeneCards
    DEK