Cell Senescence Entries for DDB2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
DDB2-deficient cells failed to undergo premature senescence induced by Ras oncogenic stress.
Primary Reference

    DDB2 Gene Information

    HGNC symbol
    DDB2 
    Aliases
    XPE; DDBB; UV-DDB2 
    Common name
    damage specific DNA binding protein 2 
    Entrez Id
    1643
    Description
    This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

    DDB2 Ontologies

    Gene Ontology
    Process: GO:6281; DNA repair
    GO:70914; UV-damage excision repair
    GO:70911; global genome nucleotide-excision repair
    GO:35518; histone H2A monoubiquitination
    GO:6289; nucleotide-excision repair
    GO:715; nucleotide-excision repair, DNA damage recognition
    GO:717; nucleotide-excision repair, DNA duplex unwinding
    GO:33683; nucleotide-excision repair, DNA incision
    GO:6295; nucleotide-excision repair, DNA incision, 3'-to lesion
    GO:6296; nucleotide-excision repair, DNA incision, 5'-to lesion
    GO:6294; nucleotide-excision repair, preincision complex assembly
    And 7 more GO terms
    Cellular component: GO:31465; Cul4B-RING E3 ubiquitin ligase complex
    GO:30054; cell junction
    GO:5654; nucleoplasm
    GO:43234; protein complex
    Function: GO:3677; DNA binding
    GO:3684; damaged DNA binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:4842; ubiquitin-protein transferase activity
    Show all GO terms

    Homologs of DDB2 in Model Organisms

    Danio rerio
    ddb2
    Mus musculus
    Ddb2
    Rattus norvegicus
    Ddb2

    In other databases

    LongevityMap
    • This gene is present as DDB2

    External links

    OMIM
    600811
    Ensembl
    ENSG00000134574
    Entrez Gene
    1643
    UniGene
    700338
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    DDB2
    GeneCards
    DDB2