Cell Senescence Entries for CYR61

Cell Types
Lung fibroblast, Foreskin fibroblast
Cell Lines
BJ, IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
By binding to integrins and heparan sulphate proteoglycans, recombinant CCN1 (CYR61) induced fibroblast senescence, resulting in cells displaying enlarged and flattened morphology, increased SA-beta-galactosidase activity, increased expression of p53 and p16 markers and upregulated expression of proinflammatory cytokines and matrix degrading enzymes.
Primary Reference

    CYR61 Gene Information

    HGNC symbol
    CYR61 
    Aliases
    CCN1; GIG1; IGFBP10 
    Common name
    cysteine rich angiogenic inducer 61 
    Entrez Id
    3491
    Description
    The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

    CYR61 Ontologies

    Gene Ontology
    Process: GO:9653; anatomical structure morphogenesis
    GO:3278; apoptotic process involved in heart morphogenesis
    GO:60413; atrial septum morphogenesis
    GO:3181; atrioventricular valve morphogenesis
    GO:8283; cell proliferation
    GO:6935; chemotaxis
    GO:60591; chondroblast differentiation
    GO:60710; chorio-allantoic fusion
    GO:30198; extracellular matrix organization
    GO:2041; intussusceptive angiogenesis
    GO:60716; labyrinthine layer blood vessel development
    And 20 more GO terms
    Cellular component: GO:31012; extracellular matrix
    GO:5615; extracellular space
    Function: GO:50840; extracellular matrix binding
    GO:8201; heparin binding
    GO:5520; insulin-like growth factor binding
    GO:5178; integrin binding
    Show all GO terms

    Homologs of CYR61 in Model Organisms

    Danio rerio
    cyr61
    Mus musculus
    Cyr61
    Rattus norvegicus
    Cyr61

    External links

    OMIM
    602369
    Ensembl
    ENSG00000142871
    Entrez Gene
    3491
    UniGene
    8867
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CYR61
    GeneCards
    CYR61