Cell Senescence Entries for CXCL1

Cell Types
Ovarian fibroblast
Cell Lines
Gro-1
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Treatment of normal ovarian stromal fibroblasts with Gro-1 (CXCL1) in serum-free medium, lead to induced cellular senescence, with cells becoming enlarged and flattened, showing growth arrest and increased SA-beta-galactosidase activity after 10 days of treatment.
Primary Reference

    CXCL1 Gene Information

    HGNC symbol
    CXCL1 
    Aliases
    FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a 
    Common name
    C-X-C motif chemokine ligand 1 
    Entrez Id
    2919
    Description
    This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

    CXCL1 Ontologies

    Gene Ontology
    Process: GO:7186; G-protein coupled receptor signaling pathway
    GO:30036; actin cytoskeleton organization
    GO:60326; cell chemotaxis
    GO:8283; cell proliferation
    GO:70098; chemokine-mediated signaling pathway
    GO:6935; chemotaxis
    GO:6955; immune response
    GO:6954; inflammatory response
    GO:35556; intracellular signal transduction
    GO:8285; negative regulation of cell proliferation
    GO:7399; nervous system development
    And 6 more GO terms
    Cellular component: GO:5576; extracellular region
    GO:5615; extracellular space
    GO:35580; specific granule lumen
    GO:1904724; tertiary granule lumen
    Function: GO:45236; CXCR chemokine receptor binding
    GO:8009; chemokine activity
    GO:8047; enzyme activator activity
    GO:8083; growth factor activity
    GO:5102; receptor binding
    Show all GO terms

    Homologs of CXCL1 in Model Organisms

    Mus musculus
    Cxcl3
    Rattus norvegicus
    Cxcl3

    External links

    OMIM
    155730
    Ensembl
    ENSG00000163739
    Entrez Gene
    2919
    UniGene
    789
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CXCL1
    GeneCards
    CXCL1