Cell Senescence Entries for CTNNAL1

Cell Types
Lung cancer, Squamous carcinoma
Cell Lines
A549, OC2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of alpha-Catulin (CTNNAL1) in cancer cell lines (OC2 and A549) dramatically decreased cell proliferation and contributed to cellular senescence.
Primary Reference

    CTNNAL1 Gene Information

    HGNC symbol
    CTNNAL1 
    Aliases
    ACRP; CLLP; alpha-CATU 
    Common name
    catenin alpha like 1 
    Entrez Id
    8727
    Description

    CTNNAL1 Ontologies

    Gene Ontology
    Process: GO:7266; Rho protein signal transduction
    GO:7155; cell adhesion
    Cellular component: GO:5856; cytoskeleton
    GO:5829; cytosol
    GO:5886; plasma membrane
    Function: GO:51015; actin filament binding
    GO:45296; cadherin binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of CTNNAL1 in Model Organisms

    Caenorhabditis elegans
    ctn-1
    Danio rerio
    ctnnal1
    Drosophila melanogaster
    alpha-catenin-relate
    Mus musculus
    Ctnnal1
    Rattus norvegicus
    Ctnnal1

    External links

    OMIM
    604785
    Ensembl
    ENSG00000119326
    Entrez Gene
    8727
    UniGene
    58488
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CTNNAL1
    GeneCards
    CTNNAL1