Cell Senescence Entries for CSNK2A1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Treatment with inhibitors or RNA interference of CKII (CSNK2A1) in lung fibroblasts (IMR-90 cells) lead to increased expression of p53 and p21 and a senescent phenotype, including an increase in SA-beta-galactosidase activity.
Primary Reference

    CSNK2A1 Gene Information

    HGNC symbol
    CSNK2A1 
    Aliases
    CKII; CK2A1; OCNDS; CSNK2A3 
    Common name
    casein kinase 2 alpha 1 
    Entrez Id
    1457
    Description
    Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]

    CSNK2A1 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:6915; apoptotic process
    GO:61077; chaperone-mediated protein folding
    GO:71174; mitotic spindle checkpoint
    GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    GO:18107; peptidyl-threonine phosphorylation
    GO:6656; phosphatidylcholine biosynthetic process
    GO:30177; positive regulation of Wnt signaling pathway
    GO:30307; positive regulation of cell growth
    GO:8284; positive regulation of cell proliferation
    GO:45732; positive regulation of protein catabolic process
    And 8 more GO terms
    Cellular component: GO:16581; NuRD complex
    GO:31519; PcG protein complex
    GO:16580; Sin3 complex
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:5956; protein kinase CK2 complex
    Function: GO:5524; ATP binding
    GO:51879; Hsp90 protein binding
    GO:16301; kinase activity
    GO:47485; protein N-terminus binding
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of CSNK2A1 in Model Organisms

    Mus musculus
    Csnk2a2
    Rattus norvegicus
    Csnk2a2

    External links

    OMIM
    115440
    Ensembl
    ENSG00000101266
    Entrez Gene
    1457
    UniGene
    644056
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CSNK2A1
    GeneCards
    CSNK2A1