Cell Senescence Entries for CPEB1

Cell Types
Lung fibroblast, Foreskin fibroblast
Cell Lines
Primary cell, WI-38
Cancer Cell?
No
Method
Overexpression, Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Knockdown of CPEB1 caused skin and lung cells to bypass the M1 stage of replicative senescence and inhibited stress-induced cellular senescence. Reintroduction of CPEB1 into the knockdown cells restored a senescence-like phenotype.
Primary Reference

    CPEB1 Gene Information

    HGNC symbol
    CPEB1 
    Aliases
    CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1 
    Common name
    cytoplasmic polyadenylation element binding protein 1 
    Entrez Id
    64506
    Description
    This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

    CPEB1 Ontologies

    Gene Ontology
    Process: GO:71230; cellular response to amino acid stimulus
    GO:71456; cellular response to hypoxia
    GO:32869; cellular response to insulin stimulus
    GO:71222; cellular response to lipopolysaccharide
    GO:6397; mRNA processing
    GO:51028; mRNA transport
    GO:8285; negative regulation of cell proliferation
    GO:2000766; negative regulation of cytoplasmic translation
    GO:30335; positive regulation of cell migration
    GO:10976; positive regulation of neuron projection development
    GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
    And 3 more GO terms
    Cellular component: GO:932; P-body
    GO:30054; cell junction
    GO:5813; centrosome
    GO:5737; cytoplasm
    GO:30425; dendrite
    GO:30426; growth cone
    GO:1990124; messenger ribonucleoprotein complex
    GO:43005; neuron projection
    GO:43025; neuronal cell body
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    And 4 more GO terms
    Function: GO:35925; mRNA 3'-UTR AU-rich region binding
    GO:3730; mRNA 3'-UTR binding
    GO:46872; metal ion binding
    GO:43022; ribosome binding
    GO:8135; translation factor activity, RNA binding
    GO:900; translation repressor activity, nucleic acid binding
    Show all GO terms

    Homologs of CPEB1 in Model Organisms

    Danio rerio
    cpeb1
    Mus musculus
    Cpeb1
    Rattus norvegicus
    Cpeb1

    External links

    OMIM
    607342
    Ensembl
    ENSG00000214575
    Entrez Gene
    64506
    UniGene
    459132
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CPEB1
    GeneCards
    CPEB1