Cell Senescence Entries for CKB

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    CKB Gene Information

    HGNC symbol
    CKB 
    Aliases
    BCK; B-CK; CKBB; HEL-211; HEL-S-29 
    Common name
    creatine kinase B 
    Entrez Id
    1152
    Description
    The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

    CKB Ontologies

    Gene Ontology
    Process: GO:30644; cellular chloride ion homeostasis
    GO:21549; cerebellum development
    GO:6600; creatine metabolic process
    GO:16310; phosphorylation
    GO:21762; substantia nigra development
    Cellular component: GO:5829; cytosol
    GO:30425; dendrite
    GO:70062; extracellular exosome
    GO:5615; extracellular space
    GO:5739; mitochondrion
    GO:43209; myelin sheath
    GO:43025; neuronal cell body
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:4111; creatine kinase activity
    GO:5515; protein binding
    GO:31625; ubiquitin protein ligase binding
    Show all GO terms

    Homologs of CKB in Model Organisms

    Danio rerio
    ckba
    Mus musculus
    Ckb
    Rattus norvegicus
    Ckb

    External links

    OMIM
    123280
    Ensembl
    ENSG00000166165
    Entrez Gene
    1152
    UniGene
    173724
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    CKB
    GeneCards
    CKB